![]() ![]() This correlation may be useful for anticipating the need for repeat plasmapheresis. ![]() Serum viscosity and electrophoresis are recommended before and after plasmapheresis in order to correlate viscosity and M-spike with patient symptoms. ![]() Hyperviscosity syndrome can also occur in multiple myeloma patients.īecause the ability of a monoclonal protein to cause hyperviscosity is affected by its concentration, molecular weight, and aggregation, sera with concentrations of monoclonal IgM greater than 4 g/dL, IgA greater than 5 g/dL, or IgG greater than 6 g/dL should be tested for hyperviscosity. When the liquids are released, they are observed to flow at different. The most common cause of serum hyperviscosity is the presence of large concentrations of IgM monoclonal proteins, and Waldenstrom macroglobulinemia accounts for 80% to 90% of hyperviscosity cases. In this qualitative test for viscosity four pipets are filled with different liquids. Funduscopic examination reveals dilation of retinal veins and flame shaped retinal hemorrhages. This is because the slope of the shear rate vs. Hyperviscosity may be manifested by nasal bleeding, blurred vision, headaches, dizziness, nystagmus, deafness, diplopia, ataxia, paresthesias, or congestive heart failure. Having a clear and prepped work area is the first crucial step to optimizing the accuracy of your viscosity measurements. Viscosity is the property of fluids to resist flow. ![]()
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